| 摘要 |
<p>Cytopathic T lymphocyte immune responses that are major histocompatibility complex Class-I mediated, in response to the expression in a cell of foreign protein, are inhibited by the presence, in the foreign protein, of a Gly-Ala repeat domain. A minimum of about 30 amino acids in the repeat domain is required to inhibit CTL immune responses. DNA segments encoding the repeat sequence are preferably inserted downstream of the sequence encoding the CTL epitope of the structural protein. Host cells, transfected with the DNA, on expression of the resultant chimeric protein, do not trigger CTL attack.</p> |
