发明名称 |
MICROCAPSULE FOR PROLONGED RELEASE OF PHYSIOLOGICALLY ACTIVE PEPTIDE |
摘要 |
This invention provides a microcapsule designed for zero order release of a physiologically active polypeptide over a period of at least two months, which is produced by preparing a water-in-oil emulsion comprising an inner aqueous layer containing about 20 to 70% (w/w) of said polypeptide and an oil layer containing a copolymer or homopolymer having a weight-average molecular weight of 7,000 to 30,000, the molar composition ratio of lactic acid/glycolic acid being 80/20 to 100/0, subjecting said water-in oil emulsion to microencapsulation. |
申请公布号 |
RU2098121(C1) |
申请公布日期 |
1997.12.10 |
申请号 |
RU19930034781 |
申请日期 |
1993.06.29 |
申请人 |
TAKEDA KEMIKAL INDASTRIZ, LTD. |
发明人 |
KHIROAKI OKADA;YAJOJ INOUE;YASUAKI OGAVA |
分类号 |
A61K9/52;A61J3/07;A61K9/16;A61K9/50;A61K9/58;A61K9/64;A61K9/66;A61K38/00;A61K38/04;A61K38/06;A61K38/09;A61K38/21;A61K38/22;A61K38/24;A61K38/43;A61K47/30;A61K47/34;A61K47/40;A61K47/44 |
主分类号 |
A61K9/52 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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