Dermal compositions comprising acrylate polymers, nicotine and low-swell clay

摘要

A dermal composition for transdermal administration of nicotine includes a blend of: one or more acrylic-based polymers in an amount of from about 10-90% w/w, nicotine in an amount of from about 3 to 15% w/w, and a cohesiveness increasing amount of one or more low-swell clays in an amount of from about 0.5 to 30% w/w. The low-swell clay has a swell of 3-23 mls as determined by the bentonite USP/NF swelling power test. Also disclosed is a method for producing a dermal composition and a method for increasing the cohesiveness of a nicotine containing dermal composition.