发明名称 |
PROCESS FOR PRODUCING 5,6,7-TRINOR-4,8-INTER-M-PHENYLENE PGI2 DERIVATIVES |
摘要 |
The present invention provides a process for preparing 5,6,7-trinor-4,8-inter-m-phenylene PGI2 derivative ¢VII! using 3a,8b-cis-dihydro-3H-5,7-dibromocyclopenta¢b!benzofuran (1) as a starting material, as well as compounds of the formulae (8) and (11) which are intermediates for the preparation of the compound of the formula (1). (see fig. I) The processes of the present invention are useful for producing m-phenylene PGI2 derivatives on an industrial scale, which are useful as pharmaceuticals. The process of the present invention has higher yield and the operations (especially purification) are easier than conventional processes.
|
申请公布号 |
CA2028626(C) |
申请公布日期 |
1997.12.09 |
申请号 |
CA19902028626 |
申请日期 |
1990.02.27 |
申请人 |
TORAY INDUSTRIES, INC. |
发明人 |
OHNO, KIYOTAKA;YOSHIWARA, HIDEO;NAGASE, HIROSHI;HOSONO, YUTAKA;WAKITA, HISANORI;KAWAI, KOJI |
分类号 |
C07D307/93;A61K31/557;A61P7/02;C07C41/16;C07C43/247;C07D;(IPC1-7):C07D307/93 |
主分类号 |
C07D307/93 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|