摘要 |
Inhibitors for matrix metalloproteases, pharmaceutical compositions containing them, and a process for using them to treat a variety of physiological conditions. The compounds of the invention have generalized formula (I) wherein R<1> represents C6-C12 alkyl; C5-C12 alkoxy; C5-C12 alkylthio; a polyether of formula R<2>O(C2H4O)a- in which a is 1 or 2 and R<2> is C1-C5 alkyl, phenyl, or benzyl; and substituted alkynyl of formula R<3>(CH2)b-CC-; in which b is 1-10 and R<3> is H-, HO-, or R<4>O- in which R<4> is C1-C3 alkyl, phenyl, or benzyl. The alkyl, phenyl, and benzyl portions of R<1> may bear at least one pharmaceutically-acceptable substituent. The subscript n is 2-4. R<5> represents phenyl; imidoyl of 4-12 carbon atoms; (3H)-benzo-1,2,3-triazin-4-on-3-yl; N-saccharinyl; (2H)-phthalazin-1-on-2-yl; 2-benzoxazolin-2-on-3-yl; 5,5-dimethyloxazolidine-2,4-dion-3-yl; and thiazolidine-2,4-dion-3-yl; with the phenyl and benzo portions of R<5> permissibly bearing at least one pharmaceutically-acceptable substituent. Pharmaceutically acceptable salts of these materials are also included. |