| 摘要 |
The invention concerns a compound of formula (I), wherein, for example: R1 is of the formula -NHC(=O)(1-4C)alkyl; R2 and R3 are hydrogen or fluoro; R4 and R5 are hydrogen or methyl; >A-B- is of the formula >C=CH-, >CHCH2, or >C(OH)CH2-(> represents two single bonds); D is O, S, SO, SO2 or -NR7; wherein R7 is hydrogen, R10CO-, R10SO2-, RaOC(Rb)=CH(C=O)-, RcC(=O)C(=O)-, RdN=C(Re)C(=O)-, RfNHC(Rg)=CHC(=O)- or R14CH(R13)(CH2)m-; wherein R10 is (1-6C)alkyl [optionally substituted by, for example, hydroxy or (1-6C)alkanoyl], R11C(O)O(1-6C)alkyl or R12O-; wherein R11 is optionally substituted (1-6C)alkyl; R12 is optionally substituted (1-6C)alkyl; Ra, Rb, Rc, Rd, Re, Rf, Rg are (1-6)alkyl; m is 0 or 1; R13 is cyano; R14 is hydrogen or (1-4C)alkyl; >X-Y- is of the formula >C=CH- or >CHCH2-; and pharmaceutically acceptable salts thereof; processes for the preparation; pharmaceutical compositions containing them and their use as antibacterial agents. |
