发明名称 |
DEOXYRIBONUCLEIC ACID FRAGMENT USEFUL AS PROBE FOR DETECTING CANCER GENE TOOK IN CHROMOSOMEAL DNA |
摘要 |
<p>A single-stranded deoxyribonucleic acid molecule having a length of less than about 25 kb comprises at least three distinct nucleotide sequences which are the sites for incorporation into a chromosome of a deoxyribonucleic acid molecule encoding a deleterious gene. Deoxyribonucleic acid probes have been prepared from such molecules and are useful as hybridization probes for detecting chromosomal deoxyribonucleic acid which has a deoxyribonucleic acid molecule encoding a deleterious gene, i.e. oncogene, incorporated therein. A single-stranded deoxyribonucleic acid molecule derived from human chromosome 22 which is about 5.8 kb in length contains sites for incorporation of a deoxyribonucleic acid molecule encoding the oncogene c-abl derived from human chromosome 9. Deoxyribonucleic acid probes have been prepared from this molecule and used to detect the abnormal Philadelphia chromosome and chronic myelocytic leukemia.</p> |
申请公布号 |
JPH09308485(A) |
申请公布日期 |
1997.12.02 |
申请号 |
JP19970017432 |
申请日期 |
1997.01.14 |
申请人 |
USA GOVERNMENT |
发明人 |
JIYON ROSU SUTEFUENSON;JIYOHANESU HENRIKUSU GUROTSUFUEN;EREONORA KURATSUSHINA HAISUTAAKAMUPU |
分类号 |
G01N33/50;C07H21/04;C12N15/00;C12N15/09;C12Q1/68;G01N33/566;G01N33/58;(IPC1-7):C12N15/09 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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