Adenovirus for delivering foreign DNA into higher eukaryotic cells

摘要

PCT No. PCT/EP94/01065 Sec. 371 Date Sep. 29, 1995 Sec. 102(e) Date Sep. 29, 1995 PCT Filed Apr. 6, 1994 PCT Pub. No. WO94/24299 PCT Pub. Date Oct. 27, 1994Viruses or cells are targeted for selective internalization into a target in vive. A molecule Specific for a receptor on the surface of the target cell is introduced onto the surface of the virus or cell. The modified virus or cell binds the receptor in vive and is internalized by the target cell. The method provides vectors for selective delivery of nucleic acids to specific cell types in vivo and a means to alter the tropism of an infectious agent.