发明名称 |
Fibrin D-domain multimer prostheses and methods for their production |
摘要 |
Methods for coating a prosthetic surface with anti-thrombogenic, or anti-coagulant, proteins are disclosed. The methods involve contacting a surface of a prosthetic material with a composition containing multimers of fibrin degradation products. These multimers, preferably D-dimers, have cross-linked D-domains. The methods of the invention are useful for providing an anti-thrombogenic coating on prosthetic implants which are exposed to a patient's blood after implantation, for example vascular grafts and artificial heart valves.
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申请公布号 |
US5693098(A) |
申请公布日期 |
1997.12.02 |
申请号 |
US19960744400 |
申请日期 |
1996.11.07 |
申请人 |
MCMASTER UNIVERSITY;ZYMOGENETICS, INC. |
发明人 |
RUBENS, FRASER D.;BISHOP, PAUL D. |
分类号 |
A61L27/34;A61L33/12;(IPC1-7):A61F2/02;A61K37/547 |
主分类号 |
A61L27/34 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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