发明名称 |
Phosphonate nucleoside analogs |
摘要 |
Provided are compounds of the following formulae: A phosphonomethoxymethyoxymethyl purine/pyrimidine derivative of the formula <IMAGE> wherein X and X' are the same or different and are hydrogen or alkyl. R and R' are the same or different and are hydrogen, alkyl, hydroxyalkyl or alkanoyl and B is a purine or pyrimidine base. A 4'-phosphonomethoxytetrahydrofuranyl-1'-purine-pyrimidine of the formula <IMAGE> wherein X and X' are the same or different and are hydrogen or alkyl, Y and Z are the same or different and are hydrogen, hydroxyl or alkyl or Y+Z is an alkenyl, an epoxide or cyclopropyl, and B is a purine or pyrimidine base.
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申请公布号 |
US5693798(A) |
申请公布日期 |
1997.12.02 |
申请号 |
US19950488337 |
申请日期 |
1995.06.07 |
申请人 |
INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC;REGA STICHTING V.Z.W |
发明人 |
KIM, CHOUNG UN;MARTIN, JOHN C.;LUH, BING UH;MISCO, PETER F. |
分类号 |
C07D239/54;C07D405/04;C07D473/00;C07D473/32;C07D473/40;C07F9/6512;C07F9/6558;C07F9/6561;C07F9/6571;C07H19/04;C07H19/10;C07H19/20;(IPC1-7):C07F9/656;C07F9/651;C07D473/18;C07D473/34 |
主分类号 |
C07D239/54 |
代理机构 |
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代理人 |
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地址 |
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