PROCESS FOR MANUFACTURING 1-(3-TRIFLUOROMETHYL) PHENYL-PROPAN-2-ONE INTERMEDIATE IN THE SYNTHESIS OF THE FENFLURAMINE

摘要

Process for manufacturing 1-(3-trifluoromethyl)phenyl-propan-2-one intermediate in the synthesis of the anorexic drug fenfluramine. The process consists in reacting the diazonium salt of the 3-trifluoromethylaniline with isopropenyl acetate in a polar solvent in presence of catalytic amounts of a cuprous or cupric salt or of a mixture thereof and, optionally, of a base and inpurifying the raw product through bisulfite complex or distillation under vacuum.