TRICYCLIC COMPOUNDS USEFUL FOR INHIBITION OF G-PROTEIN FUNCTION AND FOR TREATMENT OF PROLIFERATIVE DISEASES.

摘要

A method of inhibiting Ras function and therefore inhibiting cellular growth is disclosed. The method comprises the administration of a novel compound of formula (Ia), (Ib) or (Ic) wherein: R and R1 are H, alkyl, halogeno, OH, alkoxy, NH2, alkylamino, dialkylamino, CF3, SO3H, CO2R3, NO2, SO2NH2, or CONHR4; n is 0 or 1; R2 is a group of the formula R5C(O)-, R5CH2C(O)-, R5C(R6)2C(O)-, R5SO2-, R5CH2SO2-, R5SCH2C(O)-, R5OC(O)-, R5NHC(O)-, R5C(O)C(O)- or R5SC(O)-; R5 is alkyl, aryl, arylalkyl, arylalkenyl, heteroaryl, heteroarylalkyl, heteroarylalkenyl or heterocycloalkyl; and R6 is alkyl or C(R6)2 is a carboxyclic ring; or pharmaceutically acceptable salts thereof.