发明名称 |
POLYCYSTIC KIDNEY DISEASE GENE |
摘要 |
The present invention involves isolated nucleic acid encoding human PKD1, and sequences derived therefrom. The invention also encompasses vectors comprising these nucleic acids, host cells transformed with the vectors, and methods for producing PKD1 protein or fragments thereof. In another aspect, the invention involves isolated oligonucleotides that hybridize only to the authentic expressed PKD1 gene, and not to PKD1 homologues. In yet another aspect, the invention involves isolated mutant PKD1 genes, and their cDNA cognates. Further provided are isolated oligonucleotides that discriminate between normal and mutant versions of the PKD1 gene. Methods and compositions for treating APKD or disease conditions having the characteristics of APKD are also provided.
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申请公布号 |
WO9744457(A1) |
申请公布日期 |
1997.11.27 |
申请号 |
WO1997US08799 |
申请日期 |
1997.05.22 |
申请人 |
GENZYME CORPORATION |
发明人 |
KLINGER, KATHERINE;BURN, TIMOTHY;CONNORS, TIMOTHY;DACKOWSKI, WILLIAM;GERMINO, GREGORY;QIAN, FENG |
分类号 |
A01K67/027;A61K38/00;A61P13/12;C07K14/47;C07K16/18;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/09;C12N15/12;C12P21/08;C12Q1/68;G01N33/68;(IPC1-7):C12N15/12;C12N15/11;G01N33/53;A61K48/00;A61K38/17;C12N15/00 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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