A method of selecting for cells in vivo is disclosed. The method includes the steps of providing in vivo cells which are resistant to a selecting substance and cells non-resistant to the selecting substance. Resistant cells are selected for in vivo by providing the selecting substance in vivo at a dose non-toxic to the resistant cells and toxic to the non-resistant cells thereby replacing non-resistant cells by resistant replacement cells.
申请公布号
WO9743900(A1)
申请公布日期
1997.11.27
申请号
WO1997US08788
申请日期
1997.05.22
申请人
THE PRESIDENT AND FELLOWS OF HARVARD COLLEGE;SCHIESTL, ROBERT, H.;AUBRECHT, JIRI