发明名称 |
DERIVATIVES OF N-ACYL-ALPHA-AMINO ACID OR THEIR PHYSIOLOGICALLY ACCEPTABLE SALTS, SIMPLE ETHERS OR ESTERS, AMIDES OR HYDRATES AND COMPOSITION INHIBITING ADHESIVE PROTEINS BINDING WITH PLATELETS AND PLATELET AGGREGATION |
摘要 |
<p>N-Aroyl- alpha -aminocarboxylic acid derivatives of the formula <IMAGE> in which L, R' to R''' and Q have the meaning given in the description, can be used for the treatment or prophylaxis of diseases which are caused by the binding of adhesive proteins to blood platelets, as well as by blood platelet aggregation and cell-cell adhesion. They are prepared by removing protective groups in appropriately protected compounds or by conversion of the cyano group to the amidino group in appropriate nitriles.</p> |
申请公布号 |
RU2097378(C1) |
申请公布日期 |
1997.11.27 |
申请号 |
SU19925010974 |
申请日期 |
1992.01.31 |
申请人 |
F.KHOFFMANN-LYA ROSH AG |
发明人 |
LEO ALIG;PAUL KHADVARI;MARIANNE KHYURTSELER;MARSEL MYULLER;BEAT SHTEJNER;TOMAS VELLER |
分类号 |
A61K31/155;A61K;A61K31/165;A61K31/195;A61K31/198;A61K31/445;A61K31/451;A61P7/02;A61P7/04;C07C227/00;C07C229/00;C07C229/10;C07C233/76;C07C237/22;C07C257/18;C07C279/18;C07D;C07D207/08;C07D207/12;C07D207/16;C07D211/22;C07D211/40;C07D211/42;C07D211/44;C07D211/46;C07D211/48;C07D211/52;C07D401/06;C07D401/12;C07D451/06;C07D453/06;(IPC1-7):C07D211/42 |
主分类号 |
A61K31/155 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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