Stable pharmaceutical composition of terfenadine and ibuprofen

摘要

PCT No. PCT/US94/10972 Sec. 371 Date Jul. 3, 1996 Sec. 102(e) Date Jul. 3, 1996 PCT Filed Sep. 28, 1994 PCT Pub. No. WO95/11677 PCT Pub. Date May 4, 1995The present invention is directed to a chemically stable pharmaceutical composition containing ibuprofen in combination with terfenadine, wherein the oxidation of terfenadine to terfenadone is prevented by the presence in the composition of an alpha -hydroxy carboxylic acid.