发明名称 |
METHOD OF PREVENTING TRANSPLANT REJECTIONS |
摘要 |
A method for reducing the rejection of allografts comprising donor tissue containing antigen presenting cells (APC's), which method comprises: a) contacting the donor tissue with a photosensitizing agent to obtain a modified donor tissue; b) exposing the modified donor tissue to light having a wavelength absorbed by the photosensitizing agent for a time sufficient to deplete the APC's in the donor tissue; and c) transplanting the APC-depleted donor tissue into the tissue of a recipient. By subjecting donor tissue to photodynamic therapy, the mean survival time of grafts, particularly skin allografts, was significantly lengthened. The photosensitizer may also be part of a conjugate containing a target-specific moiety.
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申请公布号 |
PL321246(A1) |
申请公布日期 |
1997.11.24 |
申请号 |
PL19960321246 |
申请日期 |
1996.01.12 |
申请人 |
QUADRA LOGIC TECHNOLOGIES INC;UNIVERSITY OF BRITISH COLUMBIA |
发明人 |
OBOCHI MODESTUS ONUORA KAY;LEVY JULIA |
分类号 |
C07D487/22;A61K41/00;A61K45/00;A61P37/06;(IPC1-7):A61K41/00 |
主分类号 |
C07D487/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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