发明名称 |
LARGE SYNTHETIC COMPOUNDS BASED ON ELECTRON DONOR AND ELECTRON ACCEPTOR INTERACTIONS |
摘要 |
Using predetermined electron donor-electron acceptor interactions, the present invention provides for the design, synthesis and use of compounds that are capable of interacting with, competing with and even mimicking biological macromolecules. The compounds may be related structurally and/or functionally to a wide variety of biologicals including proteins, nucleic acids, lipids, carbohydrates, steroids or other compounds. In one embodiment, alternating electron donor-acceptor molecules (AEDAMers) are employed to create compounds having higher order structures including helices and pleats. These compounds may be used in a myriad of different applications, which include roles as inert carriers, antigens, biologically inactive stabilizers, drugs and enzymes. Also contemplated are combinatorial processes for creating large libraries permitting rapid screening for desired structure and/or function.
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申请公布号 |
WO9743289(A1) |
申请公布日期 |
1997.11.20 |
申请号 |
WO1997US08478 |
申请日期 |
1997.05.16 |
申请人 |
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM;IVERSON, BRENT, L.;LOKEY, R., SCOTT |
发明人 |
IVERSON, BRENT, L.;LOKEY, R., SCOTT |
分类号 |
C07D471/06;C07D519/00;C07K5/103;(IPC1-7):C07D471/06;C07K5/10;A61K47/48 |
主分类号 |
C07D471/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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