NOVEL PHYSIOLOGICALLY ACTIVE SUBSTANCE AND PROCESS FOR PRODUCING THE SAME

摘要

A novel physiologically active substance; a microorganism to be used for producing the same; and medicines containing the same as the active ingredient. A novel physiologically active substance SNF4435 represented by formula (I); a strain Streptomyces spectabilis SNF4435 isolated from the soil in the main island of Okinawa; a process comprising culturing the microorganism in a medium and separating the substance from the culture; and a process for producing the substance via chemical synthesis from its analog produced in the culture. The above substance is usable as medicines such as an immunosuppressant, an antibacterial agent for autoimmune diseases, allergic diseases and infectious diseases, and an antagonist against tolerance to anticancer drugs.