| 摘要 |
<p>The present invention is drawn to physiologically active molecules which have extended half-lives in the circulatory system of a subject, compositions which include these molecules, methods of producing the molecules, and methods of using the molecules to treat subjects. The half-lives of the physiologically active molecules are extended by modifying their structure such that they are capable of binding to the IgG protection receptor FcRp. By modifying the physiologically active molecules in this manner, the invention takes advantage of the discovery that the FcRp and the FcRn are the same receptor and that modifying physiologically active molecules such that they are capable of binding the IgG protection receptor FcRp allows these molecules to escape lysosomal catabolism and remain in the circulation of a subject for longer periods of time.</p> |
