IDENTIFICATION OF MEMBERS OF COMBINATORIAL LIBRARIES BY MASS SPECTROMETRY

摘要

The present invention is drawn to methods for characterizing the members of a combinatorial library which bind to a domain of interest. The method utilizes affinity selection in combination with mass spectrometry to provide rapid and efficient screening. The method provides information on relative affinities and molecular weights of affinity-selected compounds. The methods find use in analyzing all types of combinatorial libraries.