发明名称 |
METHODS OF TERMINAL STERILIZATION OF BIOLOGICAL PRODUCTS |
摘要 |
The invention relates to methods of sterilizing biologically active products, particularly therapeutic or prophylactic products and the compositions obtained thereby. The methods include obtaining a dried sample containing an amount of trehalose sufficient to render heat stability to the product and exposing the dried sample to heating conditions at a temperature and for a duration sufficient to substantially inactivate viruses, especially non-lipid encapsulated viruses. The drying methods include both ambient drying conditions and lyophilization. The heating conditions include any known in the art and cover a wide range of temperatures and heating times. The compositions obtained contain stable products and do not contain measurable infectious virus, particularly parvovirus.
|
申请公布号 |
WO9742980(A1) |
申请公布日期 |
1997.11.20 |
申请号 |
WO1997GB01317 |
申请日期 |
1997.05.14 |
申请人 |
|
发明人 |
KAMPINGA, JAAP;ALCOCK, ROBERT |
分类号 |
A61L2/04;A61K31/565;A61K31/57;A61K35/14;A61K35/20;A61K35/22;A61K35/50;A61K38/00;A61K38/22;A61K39/00;A61K39/395;A61K45/00;A61K47/26;A61L2/00;(IPC1-7):A61L2/00 |
主分类号 |
A61L2/04 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|