| 摘要 |
A compound having the general formula: in which: R<SUP>1 </SUP>is a member selected from the group consisting of -OCH<SUB>3</SUB>, -SCH<SUB>3</SUB>, -N(CH<SUB>3</SUB>)<SUB>2</SUB>, -NHCH<SUB>3</SUB>, -CHO, -COCH<SUB>3 </SUB>and -CHOHCH<SUB>3</SUB>; R<SUP>2 </SUP>is a member selected from the group consisting of halogen, alkyl, acyl, hydroxy, alkoxy, acyloxy, alkyl carbonate, cypionyloxy, S-alkyl and S-acyl; R<SUP>3 </SUP>is a member selected from the group consisting of alkyl, hydroxy, alkoxy and acyloxy; R<SUP>4 </SUP>is a member selected from the group consisting of hydrogen and alkyl; and X is a member selected from the group consisting of -O and -N-OR<SUP>5</SUP>, wherein R<SUP>5 </SUP>is a member selected from the group consisting of hydrogen and alkyl. In addition to providing the compounds of Formula I, the present invention provides methods wherein the compounds of Formula I are advantageously used, inter alia, to antagonize endogenous progesterone; to induce menses; to treat endometriosis; to treat dysmenorrhea; to treat endocrine hormone-dependent tumors; to treat uterine fibroids; to inhibit uterine endometrial proliferation; to induce labor; and for contraception. |
