| 摘要 |
This invention relates to the use of derivatives and analogs of formula (I) which possess adenosine agonist activity and are useful as anti-hypertensive and anti-ischemic agents, to pharmaceutical compositions including such compounds, and to their use in treating hypertension and myocardial ischemia, and to methods and intermediates used in the preparation of such compounds, <CHEM> wherein; K is CH; Q is CH2 or O: T is <CHEM> or R3O-CH2; X is straight or branched chain alkylene, cycloalkylene or cycloalkenylene group, each of which is optionally substituted by at least one CH3, CH3CH2, Cl, F, CF3 or CH3O; Y is NR4, O or S; a = 0 or 1; Z is of the formula <CHEM> Z1 is N, CR5, (CH)m-CR5 or (CH)m-N, m being 1 or 2; Z2 is N, NR6, O or S, n being 0 or 1; R1, R2, R3, R4, R5 and R6 are indepenfently H, alkyl, aryl or heterocyclyl; Ra, Rb, R', R'' as defined in the application.s |
