发明名称 |
Cyclization process for making oxazolikinones |
摘要 |
A process for the synthesis of a compound of general formula II: <IMAGE> II wherein: R2 and R3 are each independently hydrogen or C1-C4 alkyl; A is an aromatic or heteroaromatic ring system optionally substituted with one or more substituents as defined herein; and in which any ring nitrogen atom may be quaternised or oxidised; alternatively, any two substituents of the group A may combine to form a fused 5- or 6-membered saturated or partially saturated carbocyclic or heterocyclic ring in which any carbon or quaternised nitrogen atom may be substituted with any of the groups defined herein for A or in which a ring carbon atom may be oxidised; the process comprising cyclising a compound of general formula VII: <IMAGE> VII wherein A, R2 and R3 are as defined for general formula II, R20 is hydrogen, benzyl or benzyl substituted with up to five substituents selected from halo, C1-C6 alkyl, O(C1-C6 alkyl) or nitro and R21 is C1-C8 alkyl, benzyl or benzyl substituted with up to five of the substituents mentioned above for R20.
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申请公布号 |
US5688962(A) |
申请公布日期 |
1997.11.18 |
申请号 |
US19960649843 |
申请日期 |
1996.05.16 |
申请人 |
ZENECA LIMITED |
发明人 |
COX, JOHN MICHAEL;PEARSON, DAVID PHILIP JOHN;KOZAKIEWICZ, ANTHONY MARIAN;MOORE, RICHARD BUTLER;MITCHELL, GLYNN;LANGTON, DAVID WILLIAM;ELLIS, RUSSELL |
分类号 |
C07D263/20;C07D263/18;C07D263/28;(IPC1-7):C07D263/04;C07D263/16;C07D263/46 |
主分类号 |
C07D263/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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