| 摘要 |
Novel compounds of the formula <IMAGE> I wherein A is -CH=CH-B; -C 3BOND C-B; -(CH2)p-X-B, and X is a bone, -NH- or -S(O)0-2-; optionally substituted heteroaryl or benzofused heteroaryl; -C(O)-B; or <IMAGE> D is B'-(CH2)mC(O)-, B'-(CH2)q-, B'-(CH2)e-Z-(CH2)r, wherein Z is -O-, -C(O)-, phenylene, -NR8- or -S(O)0-2-, B'-(alkenylene)-; B'-(alkadienylene)-; B'-(CH2)t-Z-(alkenylene), B'-(CH2)f-V-(CH2)g-, wherein V is cycloalkylene, B'-(CH2)t-V-(alkenylene) or B'-(alkenylene)-V-(CH2)t-, B'-(CH2)a-Z-(CH2)b-V-(CH2)d-, T-(CH2)s-, wherein T is cycloalkyl; naphthylmethyl or optionally substituted heteroarylmethyl; B is optionally substituted phenyl; B' is naphthyl, optionally substituted heteroaryl or optionally substituted phenyl; R is hydrogen, fluoro, alkyl, alkenyl, alkynyl, or B-(CH2)n-; R4 is optionally substituted phenyl, indanyl, benzofuranyl, tetrahydronaphthyl, pyridyl, pyrazinyl, pyrimidinyl or quinolyl; are disclosed, the method of using compounds of the formula II <IMAGE> II wherein R20 is optionally substituted phenyl, naphthyl, heteroaryl, or benzofused heteroaryl, R21, R22 and R23 are H or R20; E, F and G are independently a bond; cycloalkylene; alkylene; alkenylene; alkynylene; a substituted alkylene, alkenylene or alkynylene chain; an interrupted alkylene, alkenylene or alkynylene chain; or an interrupted alkylene, alkenylene or alkynylene chain substituted by one or more substituents; or one of R21-E and R22-F is selected from the group consisting of halogeno, OH, alkoxy, -OC(O)R5, -NR10R11, -SH or -S(alkyl); R5 is alkyl, phenyl, R14-phenyl, benzyl or R14-benzyl; R10 and R11 are independently selected from H and lower alkyl, or a pharmaceutically acceptable salt thereof, in a pharmaceutically aceptable carrier as hypocholesterolemic agents is also disclosed.
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