发明名称 |
Anti-receptor and growth blocking antibodies to the vitamin B12/transcobalamin II receptor and binding sites |
摘要 |
There is disclosed anti-receptor and growth blocking agents to the vitamin B12/transcobalamin II receptor and binding sites. The anti-receptor and growth blocking agents antagonize or modulate the vitamin B12/transcobalamin II receptor or binding sites, causing cellular depletion of vitamin B12, thus preventing or inhibiting cell division or causing apoptosis. Anti-receptor and growth blocking agents of the present invention include proteins (such as antibodies and antibody derivatives), peptides and small organic molecules. In a preferred embodiment, the anti-receptor agent is an antibody to the vitamin B12/transcobalamin II receptor.
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申请公布号 |
US5688504(A) |
申请公布日期 |
1997.11.18 |
申请号 |
US19940306504 |
申请日期 |
1994.09.13 |
申请人 |
RECEPTAGEN CORPORATION |
发明人 |
MORGAN, JR., ALTON CHARLES |
分类号 |
C12N15/02;A61K38/00;A61K39/395;A61P35/00;C07K;C07K16/18;C07K16/28;C12P21/08;C12R1/91;(IPC1-7):A61K39/00 |
主分类号 |
C12N15/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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