THIO DERIVATIVES OF HYDROXAMIC ACIDS

摘要

Compounds of formula (I), wherein R<1> is an aryl, arylC1-6alkyl, heteroaryl or heteroarylC1-6alkyl group; R<2> is hydrogen, C1-8alkyl, C2-6alkenyl, C2-6alkynyl, C3-8cycloalkyl, heteroaryl, heterocyclyl, arylC1-6alkyl, heteroarylC1-6alkyl, heterocyclylC1-6alkyl or C3-8cycloalkylC1-6alkyl; R<3> is C1-6alkyl, C2-6alkenyl, aryl, C1-6alkyl, heteroarylC1-6alkyl or the side-chain of a naturally occurring amino acid; R<4> is hydrogen, C1-6alkyl, C3-8cycloalkyl, C4-8cycloalkenyl, arylC1-6alkyl, heteroarylC1-6alkyl or heterocyclylC1-6alkyl; R<5> is hydrogen or C1-6alkyl; or R<4> and R<5> together with the nitrogen atom to which they are joined form a heterocyclic ring; wherein any group or ring, in R<1>-R<5>, is optionally substituted; or pharmaceutically acceptable salts or in vivo hydrolysable esters thereof, are described as inhibitors of the production of Tumour Necrosis Factor and/or one or more matrix metalloproteinase enzymes. Compositions containing them and their preparation are also described.