发明名称 |
SUBSTITUTED IMIDAZOLIUM SALTS AND THEIR USE FOR THE INHIBITION OF PROTEIN AGEING |
摘要 |
The present invention relates to compositions and methods for inhibiting and reversing nonenzymatic cross-linking (protein ageing). Accordingly, compositions are disclosed which comprise substituted imidazolium compounds capable of inhibiting the formation of, as well as reversing already formed, advanced glycosylation end products of target proteins. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein ageing can be treated.
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申请公布号 |
CA2253788(A1) |
申请公布日期 |
1997.11.13 |
申请号 |
CA19972253788 |
申请日期 |
1997.05.02 |
申请人 |
ALTEON INC. |
发明人 |
WAGLE, DILIP R.;HWANG, SAN-BAO;MALLON, VERONICA M. |
分类号 |
A23L3/3526;A23L3/3544;A61K8/49;A61K31/00;A61K31/415;A61K31/4164;A61P39/00;A61P39/06;A61Q11/00;A61Q19/08;C07D233/56;C07D233/60;C07D233/61;C07D521/00;(IPC1-7):C07D233/56;A23L3/352 |
主分类号 |
A23L3/3526 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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