<p>The invention concerns a process for producing an alkylated nucleoside-3'-phosphate having a nucleobase, a pentose and a phosphate group, consisting of the following steps: (a) reaction of nucleoside-3'-phophate having protecting groups with an alkylating substance and (b) splitting off of the protecting groups. Furthermore, the invention concerns alkylated nucleoside-3'-phosphates as well as their use in tumour therapy and as a comparison substance in the <32>P-post-labelling process.</p>
申请公布号
DE19618727(A1)
申请公布日期
1997.11.13
申请号
DE1996118727
申请日期
1996.05.09
申请人
DEUTSCHES KREBSFORSCHUNGSZENTRUM STIFTUNG DES OEFFENTLICHEN RECHTS, 69120 HEIDELBERG, DE
发明人
WIESLER, MANFRED, PROF. DR., 69126 HEIDELBERG, DE;KLIEM, HANS-CHRISTIAN, DR., 64646 HEPPENHEIM, DE