发明名称 |
Mutated ras peptides for generation of cd8<sup>+</sup> cytotoxic t lymphocytes |
摘要 |
Mutant ras oncogene peptides may induce specific anti-ras cellular immune responses in vaccinated patients. Moreover, a human CD8+ CTL epitope(s) reflecting a specific point mutation in the K-ras oncogene at codon 12 was identified. The mutant ras peptide has implications for both active and passive immunotherapies in selected carcinoma patients. A nested 10-mer peptide was identified [i.e., ras5-14(Asp12)], which was shown to bind to HLA-A2 and display specific functional capacity for expansion of the in vivo-primed CD8+ CTL precursors. |
申请公布号 |
AU2734397(A) |
申请公布日期 |
1997.11.12 |
申请号 |
AU19970027343 |
申请日期 |
1997.04.17 |
申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED |
发明人 |
JEFFREY SCHLOM;SCOTT ABRAMS |
分类号 |
A61K39/00;C07K14/82;C12N5/08;C12N15/12 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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