Antigenically reactive regions of the hepatitis a virus polyprotein

摘要

Antigenically reactive regions of the Hepatitis A virus polyprotein are provided. These antigenically reactive regions, and polypeptides and proteins comprising these antigenically reactive regions, provide a sensitive and specific immunological hepatitis A virus detection assay. The specific use of regions derived from the nonstructural regions of the polypeptide provides the basis for determining immunity derived from prior or present infection by the Hepatitis A virus and allows one to distinguish between an immunological response derived from infection and that derived from immunization.