发明名称 Methods for enhanced retrovirus-mediated gene transfer
摘要 A method to increase the efficiency of transduction of hematopoietic cells by retroviruses includes infecting the cells in the presence of fibronectin or fibronectin fragments. The fibronectin and fibronectin fragments significantly enhance retroviral-mediated gene transfer into the hematopoietic cells, particularly including committed progenitors and primitive hematopoietic stem cells. The invention also provides improved methods for somatic gene therapy capitalizing on the enhanced gene transfer, and hematopoietic cellular populations.
申请公布号 US5686278(A) 申请公布日期 1997.11.11
申请号 US19940218355 申请日期 1994.03.25
申请人 INDIANA UNIVERSITY FOUNDATION;UNIV NORTHWESTERN 发明人 WILLIAMS, DAVID A.;PATEL, VIKRAM P.
分类号 C12N15/09;A01K67/027;A61K35/28;A61K35/76;A61K38/00;A61K38/04;A61K38/16;A61K38/22;A61K38/27;A61K38/46;A61K39/395;A61K47/48;A61K48/00;A61P7/00;A61P35/00;A61P43/00;C07H21/04;C07J1/00;C07K14/435;C07K14/47;C07K14/78;C07K17/14;C07K19/00;C12M3/00;C12N5/10;C12N9/78;C12N15/48;C12N15/63;C12N15/867;(IPC1-7):C12N15/09 主分类号 C12N15/09
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