| 发明名称 |
Inhibitors of farnesyl-protein transferase |
| 摘要 |
The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.
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| 申请公布号 |
US5686472(A) |
申请公布日期 |
1997.11.11 |
| 申请号 |
US19930143943 |
申请日期 |
1993.10.27 |
| 申请人 |
MERCK & CO., INC. |
发明人 |
ANTHONY, NEVILLE J.;DESOLMS, S. JANE;LEE, DECEASED, TA JYH |
| 分类号 |
A61K31/195;A61K31/215;A61K31/365;A61P35/00;A61P35/02;A61P43/00;C07C323/25;C07C323/52;C07C323/56;C07C323/57;C07C323/58;C07C323/59;C07D307/33;(IPC1-7):C07D213/28;C07C381/00;C07C729/00;A61K31/41 |
主分类号 |
A61K31/195 |
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