发明名称 |
Methods of using low molecular weight heparins for treatment of pathological processes |
摘要 |
The present invention relates to methods for the prevention and/or treatment of pathological processes involving the induction of TNF- alpha secretion comprising a pharmaceutically acceptable carrier and a low molecular Weight heparin (LMWH). In the pharmaceutical compositions of the present invention, the LMWH present in a low effective dose and is administered at intervals of about 5-8 days. Furthermore, the LMWH is capable of inhibiting in vitro TNF- alpha secretion by resting T cells and/or macrophages in response to T cell-specific antigens, mitogens, macrophage activators, disrupted extracellular matrix (dECM), laminin, fibronectin, and the like.
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申请公布号 |
US5686431(A) |
申请公布日期 |
1997.11.11 |
申请号 |
US19950457655 |
申请日期 |
1995.06.01 |
申请人 |
YEDA RESEARCH AND DEVELOPMENT CO., LTD. |
发明人 |
COHEN, IRUN R.;LIDER, OFER;HERSHKOVIZ, RAMI |
分类号 |
A61K31/715;A61K;A61K31/727;A61P1/00;A61P1/02;A61P3/08;A61P9/10;A61P29/00;A61P31/12;A61P37/00;A61P37/08;(IPC1-7):A61K31/725;C08B37/10 |
主分类号 |
A61K31/715 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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