发明名称 |
2-£4-(kinazolinylmetylamino)benzamido|-4-(tetrazolyl)smörsyrederivater med anti-tumor-aktivitet |
摘要 |
<p>The invention relates to quinazoline derivatives, or pharmaceutically-acceptable salts thereof, which possess anti-tumour activity; to processes for their manufacture; and to pharmaceutical compositions containing them. The invention provides a quinazoline of the formula:- <CHEM> wherein R<1> is (1-4C)alkyl; the quinazoline ring may optionally bear one or two further substituents selected from halogeno, (1-4C)alkyl and (1-4C)alkoxy; R<2> is hydrogen or (1-4C)alkyl; R<3> includes hydrogen and (1-4C)alkyl; and Ar is optionally substituted phenylene or heterocyclene; or a pharmaceutically-acceptable salt or ester thereof.</p> |
申请公布号 |
NO301543(B1) |
申请公布日期 |
1997.11.10 |
申请号 |
NO19930000881 |
申请日期 |
1993.03.10 |
申请人 |
ZENECA LTD;BRITISH TECHNOLOGY GROUP LTD |
发明人 |
PEGG, STEPHEN JOHN;WARDLEWORTH, JAMES MICHAEL |
分类号 |
A61K31/505;A61K31/495;A61K31/517;A61P35/00;C07D239/88;C07D239/95;C07D257/04;C07D401/14;C07D403/12;(IPC1-7):C07D403/12 |
主分类号 |
A61K31/505 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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