Methods of diagnosing a clinical subtype of crohn's disease with features of ulcerative colitis

摘要

The present invention provides a method of diagnosing a clinical subtype of Crohn's disease (CD) by determining whether perinuclear anti-neutrophil antibodies (pANCA) are present in a patient with CD, where the presence of pANCA indicates the clinical subtype of CD with features of ulcerative colitis (UC). The invention also provides a method of diagnosing a clinical subtype of CD by detecting an Arg241 allele at an ICAM-1 locus in a patient with CD, where the Arg241 allele indicates a clinical subtype of CD with features of ulcerative colitis. In addition, the invention provides a method of diagnosing a pANCA-positive subtype of CD by detecting an Arg241 allele at an ICAM-1 locus in a patient with CD, where the Arg241 allele indicates the pANCA-positive subtype of CD.