发明名称 Thieno-pyridine sulfonamides, derivatives thereof and related compounds that modulate the activity of endothelin
摘要 Methods, compositions, and compounds for modulating the activity of an endothelin peptide are provided. The methods use compositions that contain compounds that include those of the formula: <IMAGE> include O, S, and NH; Y is selected from O+ and N, and R1 and R2 are each selected independently from among alkyl, lower alkenyl, lower alkynyl, lower haloalkyl, halide, pseudohalide or H, except that R2 is not halide. R3, R4 and R5 are selected from among groups that include hydrogen, halide, alkoxy, alkyl, haloalkyl; and R7 is selected from groups that include (CH2)rR18, in which r is 0 to 6 and R18 is selected from groups that include aryl, particularly pyrmidinyl and phenyl. The methods are effected by contacting endothelin receptors with one or more of the compounds or with compositions containing one or more of the compounds prior to, simultaneously with, or subsequent to contacting the receptors with an endothelin peptide.
申请公布号 AU2664197(A) 申请公布日期 1997.11.07
申请号 AU19970026641 申请日期 1997.04.09
申请人 TEXAS BIOTECHNOLOGY CORPORATION 发明人 ERIK JOEL VERNER
分类号 A01N43/42;A61K31/381;A61K31/407;A61K31/4365;A61K31/4741;A61K31/4743;A61K31/4745;C07D471/04;C07D491/04;C07D495/04 主分类号 A01N43/42
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