The mechanism of hypertension following acute NO synthase blockade is via endothelin-mediated vasoconstriction. Thus, NO appears to inhibit endothelin activity by blocking its expression and not as a chronic direct acting vasodilator. Administration of an endothelin antagonist to a patient in a 'normal' physiological state may result in specific regional vasodilation. This treatment finds utility in the treatment of erectile dysfunction. 00000
申请公布号
WO9733608(A3)
申请公布日期
1997.11.06
申请号
WO1997CA00169
申请日期
1997.03.13
申请人
QUEEN'S UNIVERSITY AT KINGSTON;BANTING, JAMES, D.;HEATON, JEREMY, P., W.;ADAMS, MICHAEL, A.
发明人
BANTING, JAMES, D.;HEATON, JEREMY, P., W.;ADAMS, MICHAEL, A.