An anti-tumour agent comprises a macromolecular carrier moiety, an active alkylating moiety which is a nitrogen mustard and a stabilising moiety which links the active alkylating moiety with the carrier moiety. The stabilising moiety is an oligopeptide which is capable of being cleaved by a tumour-associated protease and which stabilises the active alkylating moiety by electron withdrawal and/or by inducing formation of aggregates. 00000
申请公布号
WO9736616(A3)
申请公布日期
1997.11.06
申请号
WO1997GB00917
申请日期
1997.04.01
申请人
THE UNIVERSITY OF BIRMINGHAM;SEYMOUR, LEONARD, WILLIAM;SCHACHT, ETIENNE, HONORE;SOYEZ, HEIDI