IMPROVING BINDING AFFINITY OF ANTIGENIC PEPTIDES FOR MHC MOLECULES

摘要

This invention provides methods of improving the binding affinity of a peptide epitope for MHC Class II molecules by attaching to the N-terminus of the peptide epitope a hydrophobic amino acid or a peptide containing a hydrophobic amino acid. The invention also provides complexes between the modified antigenic peptides and MCH Class II molecules, as well as method for treating deleterious immune responses.