发明名称 |
ANTIVIRAL RICIN-LIKE PROTEINS |
摘要 |
The present invention provides a protein having an A chain of a ricin-like toxin, a B chain of a ricin-like toxin and a heterologous linker amino acid sequence, linking the A and B chains. The linker sequence contains a cleavage recognition site for a retroviral protease such as HIV or an HTLV protease. The invention also relates to a nucleic acid molecule encoding the protein and to expression vectors incorporating the nucleic acid molecule. Also provided is a method of inhibiting or destroying mammalian cells infected with a retrovirus utilizing the proteins of the invention; and pharmaceutical compositions for treating HIV infections and human T-cell leukemias involving HTLV.
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申请公布号 |
CA2252799(A1) |
申请公布日期 |
1997.11.06 |
申请号 |
CA19972252799 |
申请日期 |
1997.04.29 |
申请人 |
DE NOVO ENZYME CORPORATION |
发明人 |
BORGFORD, THOR |
分类号 |
A61K38/00;A61K38/16;C07K14/415;C12N15/29;(IPC1-7):C12N15/62;C07K19/00 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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