Stereoisomerische Anreicherung von 2-Amino-3-hydroxy-3-phenyl-propionsäuren
摘要
<p>Mixtures of enantiomeric D,L-threo 2-amino-3-hydroxy-3-phenylpropionic acids can be stereoisomerically enriched by contacting the mixture with a D-threonine aldolase. In a typical embodiment, D- and L-threo 2-amino-3-hydroxy-3-(4-methylsulfonylphenyl)propionic acid is treated with D-threonine aldolase to produce L-threo 2-amino-3-hydroxy-3-(4-methylsulfonylphenyl)propionic acid with a high ee. The benzaldehyde and amino acid formed from the D-threo isomer can be recycled.</p>
申请公布号
DE69220701(T2)
申请公布日期
1997.11.06
申请号
DE1992620701T
申请日期
1992.03.19
申请人
CELGENE CORP., WARREN, N.J., US
发明人
ZEITLIN, ANDREW L., SOMERVILLE, NEW JERSEY 08876, US;RAJU, MUPPALA S., BRIDGEWATER, NEW JERSEY 08807, US;STIRLING, DAVID I., FANWOOD, NEW JERSEY 07023, US