发明名称 |
5,6,7,8-TETRAHYDROPYRIDO[2,3-d]PYRIMIDINES |
摘要 |
Glutamic acid derivatives in which the amino group is substituted with a 2-amino-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-6-ylalkyl-Z-carbonyl group, in which Z is a divalent, five-membered, nitrogen-containing heterocyclic ring system optionally containing a sulfur or nitrogen atom as a second hetero ring member, are antineoplastic agents. A typical embodiment is N-{3-[2-(2-amino-4-hydroxy-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-6-yl)ethyl]-pyrazol-5-ylcarbonyl}-L-glutamic acid.
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申请公布号 |
WO9741115(A1) |
申请公布日期 |
1997.11.06 |
申请号 |
WO1996US14822 |
申请日期 |
1996.09.17 |
申请人 |
THE TRUSTEES OF PRINCETON UNIVERSITY;ELI LILLY AND COMPANY;TAYLOR, EDWARD, C.;SHIH, CHUAN;LEE, KOO;GOSSETT, LYNN, S. |
发明人 |
TAYLOR, EDWARD, C.;SHIH, CHUAN;LEE, KOO;GOSSETT, LYNN, S. |
分类号 |
A61K31/00;A61K31/505;A61K31/519;A61K31/529;A61K38/00;A61P35/00;C07D471/04;C07K5/078;(IPC1-7):C07D401/14 |
主分类号 |
A61K31/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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