METHOD AND MEANS FOR DISRUPTION OF p53 AND RB INTERACTION

摘要

p53 mediates induction of apoptosis in RB mutant cells. p53 and RB interact at identified binding sites and interference with such interaction may be used in induction of apoptosis, useful for example in anti-tumor therapy, and modulation of other p53-mediated activities and properties of p53. Inhibitors or p53/RB interaction include peptide fragments of p53 and variants thereof, and non-peptidyl analogues and mimetics thereof. Assay methods and means allow for screening for inhibitor compounds which may induce apoptosis or modulate other p53-mediated activities or properties or p53 and be useful in therapeutic contexts.