Medical use of an antibody or antibody fragment against the extracellular domain of Met for the prevention of metastasis

摘要

The present invention relates to use of a substance which prevents HGF/SF from binding with Met in the preparation of a medicament for use in a method of preventing tumor cell metastasis, wherein in said method, a tumor-bearing mammal is treated with an effective inhibiting amount of said substance. The substance can e.g. be a HGF/SF variant, HGF/SF mimetic or antibody or antibody fragment against HGF/SF, a Met variant, Met mimetic or antibody or antibody fragment against Met or a polyclonal antibody generated against a peptide sequence within the extracellular domain of Met. <IMAGE>