-i(STREPTOCOCCUS PNEUMONIAE) CAPSULAR POLYSACCHARIDE GENES AND FLANKING REGIONS

摘要

Disclosed is the identification, cloning and sequencing of flanking DNA regions common to all polysaccharide capsule types in Streptococcus pneumoniae. Also disclosed are particular type-specific genes and gene products that direct the formation of the Streptococcus pneumoniae serotype-specific polysaccharide capsule. Methods are provided for detecting Streptococcus pneumoniae. and for constructin gene cassettes that may be transferred as a unit during transformation and used to direct the expression of specific serotyes of Streptococcus pneumoniae capsules.