发明名称 |
3-aminopyrroles, methods for their synthesis and for their pharmaceutical use |
摘要 |
The invention is directed to 3-aminopyrroles of formula I, which are largely new, to methods for the preparation and to their use as medicinal agents and preparations, as well as to anti-convulsive or analgesic preparations containing these 3-aminopyrroles. Disubstituted and monosubstituted amino groups are claimed as 3-amino substituents. The invention pursues the objective of developing largely new 3-aminopyrroles, which have CNS activity, particularly ones which anti-convulsive or analgesic properties, as well as methods for their preparation and their use as medicinal preparations. Pursuant to the invention, the synthesis is carried out by cyclizing open-chain precursors, such as aminoacrylic acid derivative, or by modifying pyrroles.
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申请公布号 |
US5684160(A) |
申请公布日期 |
1997.11.04 |
申请号 |
US19950446000 |
申请日期 |
1995.05.19 |
申请人 |
ARZNEIMETTELWERK DRESDEN GMBH |
发明人 |
SCHARFENBERG, PETER;LIEBSCHER, JUERGEN;KNOLL, ALEXANDER;USCHMAJEW, ALEKSEJ;ROLFS, ANDREAS;LOHMAN, DIETER;FAUST, GOTTFRIED;MORGENSTERN, EVELINE |
分类号 |
C07D401/04;A61K9/20;A61K9/48;A61K31/40;A61K31/4427;A61K31/445;A61K31/495;A61K31/535;A61K31/5377;A61P25/04;A61P25/08;A61P29/00;C07D207/34;C07D403/04;C07D413/04;C07D417/04;(IPC1-7):C07D207/34 |
主分类号 |
C07D401/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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