PRODUCTION OF ACTIVE PROTEIN COMPOSITION

摘要

PROBLEM TO BE SOLVED: To produce a safe active protein composition without containing any infectious contaminating viruses by physically or chemically removing a thermally unstable protein from a solution containing a biologically active protein and inactivating infectious viruses. SOLUTION: A thermally unstable protein part is separated and removed from a solution (e.g. a blood plasma) containing a biologically active protein (e.g. plasminogen) according to a physical or a chemical method, e.g. an enzymic proteolysis and the resultant product after removing the thermally unstable protein part is then heated at a temperature of at least 50οC for at least 10hr in order to sufficiently inactivate all the contaminating infectious viruses. Thereby, the inactivating treatment of the viruses according to a thermal pasteurization to afford the objective safe and biologically active protein composition without substantially containing any contaminating viruses having infectivity.