Highly sensitive method for detecting environmental insults

摘要

PCT No. PCT/US93/11527 Sec. 371 Date Oct. 6, 1994 Sec. 102(e) Date Oct. 6, 1994 PCT Filed Dec. 2, 1993 PCT Pub. No. WO94/13831 PCT Pub. Date Jun. 23, 1994Subtle changes in environmental stress can now be detected and measured at sublethal levels as a generic response to environmental stress. The present invention provides a method to detect changes in the environmental stress level. The stress change is indicated as a change in the luminescence output of a genetically engineered microorganism. In the present invention, the luminescence gene complex is under the control of a stress inducible promoter.